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    Jubilant Biosys PathArt

    Category  Cross-Omics>Pathway Knowledge Bases/Databases/Tools

    Abstract  PathArt is a curated database of biomolecular interactions
    with tools for searching, analysis and visualization of data. PathArt
    consists of three (3) modules: 1) The Pathway module (PathArt Core);
    2) The Interaction Map Module and 3) The Drug-Target Module. This
    product could be an invaluable tool for scientists working on target
    identification and validation, biomarker discovery, systems biology,
    microarray analysis and expression profiling.

    The Pathway module (PathArt Core):

    PathArt Core is a comprehensive collection of curated data from
    literature as well as public domain databases for more than 2,100
    signaling and metabolic pathways. PathArt includes a database
    component and dynamic pathway articulator component, which builds
    directed acyclic graphs from molecular interaction networks.

    Diseases Covered (31) -
    Asthma, Atherosclerosis, Alzheimer's, AIDS, Chronic Myeloid
    Leukemia, Chronic Obstructive Pulmonary Disease (Chronic
    Bronchitis and Emphysema), Diabetes Type II, Breast Cancer, Colon
    Cancer, Glioblastoma, Lung Cancer, Prostate Cancer, Parkinson's
    Disease, Pancreatic Cancer, Melanoma, Multiple Sclerosis, Erectile
    Dysfunction, Obesity, Osteoarthritis, Osteoporosis, Ovarian Cancer,
    Rheumatoid Arthritis, Inflammatory Bowel Disease, Ulcerative Colitis,
    Crohn's Disease, Schizophrenia, Depression, Hypertension, Bipolar
    Disorder, Liver Cancer, and Stomach Cancer.

    Physiologies covered (19) -

    Apoptosis, Cell Adhesion, Cell-cycle, DNA Repair, Development, Pain,
    Growth and Differentiation, Inflammation, Keratinocyte Differentiation,
    Myogenesis, Neurogenesis, Protein Families, Skeletal Development,
    Thrombopoiesis, Angiogenesis, Erythropoiesis, Lymphopoiesis,
    Monopoiesis and others.

    Interaction Maps:

    Interaction Maps (IMaps) is a manually curated database with more
    than 120,000 interactions for 17 organisms captured from over 70,000
    abstracts. Extensive data coverage on protein-protein, protein-small
    molecule, protein-RNA, protein-DNA and protein-drug interactions
    gives this database the competitive edge. Its data content grows at a
    rate of more than 20,000 interactions per quarter.

    Druggable-Target Module:

    The Druggable-Target module garners and contains manually curated
    data on toxicity, Pharmacokinetics and Pharmacodynamics (PK/PD),
    toxicogenomics etc., as well as public domain data on 300 anticancer
    drug molecules which can be ported to System Data Format (SDF)
    files. This data also contains disease centric target information.

    PathArt Data Features include:

    1) Three (3) different modules that are 'integrated' - PathArt (pathways
    module), Imaps (biomolecular interaction module) and the druggable
    target module (focus on anticancer drugs).

    2) Classification of pathways into canonical and non canonical,
    containing organism, organ, and cell-type specific data.

    3) Manually curated data for disease/physiology specific interactions,
    mutations and knockouts.

    4) All the relevant details about the interaction(s) such as, the
    mechanism, mode, model/organism etc., have been captured.

    5) Functional annotation for genes from over 12 public domain
    databases.

    PathArt Application Features include:

    1) Dynamically generated interaction networks that depict interaction
    data and a tabular report of the interactions.

    2) Search types provided include pathway, component, public domain
    id, effect and inhibitor-based searches.

    3) Data export options for systems biology markup language (SBML),
    hypertext markup language (HTML) and extensible markup language
    XML formats.

    4) Homolog mapping for genes across species in PathArt and
    Interaction Maps.

    5) Isoform mapping for genes captured in the database.

    6) Search based on component name, 'Shortest path' and/or 'All paths'
    is provided in the Interaction Maps module.

    7) An option to map components from Interaction maps to PathArt, in
    order to view them in a pathway perspective.

    8) Ability to highlight the genes that inhibitor, drug, mutation or
    knockout information is available in the graphical representation.

    9) Custom coloring of components based on cellular location,
    component type, etc., and also based on parameters such as
    expression ratios (for microarray data analysis).

    10) Tagging of mutations in enzymes in metabolic pathways along with
    metabolic disorder information.

    11) Built-in microarray data analysis capabilities which include various
    normalization and clustering algorithms.

    12) Mapping of relevant gene sets from a statistical analysis result
    onto pathways.

    13) Two way integration with widely used microarray analysis tools
    such as GeneSpring (see G6G Product Number 20003 and G6G
    Product Number 20056) and Spotfire (see G6G Product Number
    20061).

    System Requirements  Contact manufacturer

    Manufacturer   Home office; see web site for international locations.

    Jubilant Biosys Ltd.
    #96, Industrial Suburb,
    2nd Stage, Yeshwantpur,
    Bangalore - 560 022,
    India.
    Tel.: +91 80 66628400
    Fax.: +91 80 66628333
    contact@jubilantbiosys.com

    Manufacturer's Web Site  www.jubilantbiosys.com/dppa.htm

    Price  Contact manufacturer

    G6G Product Number  20060

    G6G Manufacturer Number  101600
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