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    ASCENTA System v2.0

    Category  Cross-Omics>Biomarker Discovery/Analysis/Tools

    Abstract  The ASCENTA System v2.0 from Gene Logic allows you to
    immediately access microarray expression data from difficult-to-obtain,
    well annotated diseased and normal tissue sample sets [defined by
    relevant clinical parameters (i.e. morphology, disease stage, gender,
    age, medication)] that will empower your drug target and biomarker
    discovery efforts. Combined with this rich content, you can use
    ASCENTA System’s advanced analysis tools to realize significant time,
    cost, and resource savings.

    This system facilitates rapid candidate target and biomarker discovery
    by providing knowledge of:

    1) Regulation of a target's gene expression profile across a panorama
    of human diseases and normal tissues, in addition to several animal
    and cell culture model systems.

    2) Other genes that pattern match an expression profile for selected
    target genes of interest.

    3) Expression profiles across disease and normal tissues for entire
    gene families related to target genes of interest.

    4) Regulation of differential gene expression across metabolic and
    regulatory pathways.

    The new ASCENTA System v2.0 contains the following
    features/capabilities:

    1) NEW! The PathwayPrioritizer Report allows you to quickly analyze and
    rank pathways with respect to differential gene expression events
    between altered biological states, and learn more about pathways of
    interest using Gene Logic’s highly informative Pathway Reports.

    2) NEW! The Marker/X Tool can find, sort, and rank genes with unique
    expression and differential regulation patterns in human diseases to
    identify potential biomarkers and drug targets.

    3) NEW! The new Global Mean e-Northern Tool helps you characterize
    genes that have tissue specific or unique expression profiles across
    human tissues and diseases.

    4) UPDATED! Diff/X Reports now provide summary information,
    allowing you to quickly examine key regulation events for genes,
    pathways, and gene families with respect to tissue and therapeutic area
    classification. You can find focal points of differential gene expression
    and/or quickly identify genes linked to pathways commonly regulated in
    related diseases.

    5) PLUS! The Match/X Tool finds genes that share the same patterns of
    expression as a gene of interest. Study Data allows you to examine
    changes in target gene expression within the context of carefully
    controlled laboratory studies of cell lines and animal models. Use Gene
    Logic’s intuitive Gene Family Browser to learn about structural
    relationships between genes grouped into 11 broad gene families,
    newly sub-curated into more than 80 smaller sub-classifications.

    A Rich and Reliable Data Resource --

    1) ASCENTA System contains gene expression profiles from over 8,700
    human, rat and mouse samples curated into over 1,600 sample sets
    critically relevant to the key therapeutic areas of inflammatory disease,
    cardiovascular disease, oncology, central nervous system disorders,
    and metabolic disorders. The ASCENTA System also includes a wide
    range of normal human, rat, and mouse tissues for comparison.

    2) Gene expression data are obtained from Affymetrix GeneChip
    microarrays processed using rigorous quality control procedures from
    initial acquisition through RNA isolation, labeling, microarray
    processing, imaging, normalization, and analysis.

    3) A highly intuitive user interface allows you to conduct data analysis in
    an integrated, informative environment designed to interrelate gene
    expression data with biological significance.

    4) Gene expression data for sample sets of interest can be queried by
    individual gene, gene family, biological pathway, gene ontology class, or
    by genome-wide comparisons.

    Note 1: Available through subscription, the ASCENTA System is a user-
    friendly web-based system for life scientists at any level of experience.

    Note 2: See G6G Product Number 20123 for additional product info
    from this manufacturer.

    System Requirements  

    Contact manufacturer

    Manufacturer   Home office; see web site for international locations.

    Gene Logic an Ocimum Biosolutions Company
    50 West Watkins Mill Road
    Gaithersburg, MD 20878
    Telephone: 301.987.1700
    Toll Free: 800.GENELOGIC (800.436.3564)
    Fax. 301.987.1701
    gxsupport@genelogic.com
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