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    ImaGene CGH

    Category  Genomics>Genetic Data Analysis/Tools

    Abstract  ImaGene aCGH Module is a leading edge microarray-based
    Comparative Genomic Hybridization (CGH) analysis tool. It was
    developed to provide researchers with an advanced tool to assess DNA
    copy number variations. ImaGene aCGH Module is fully integrated into
    ImaGene 8.0 (See G6G Product Number 20128), presented as an
    additional analysis capability of this pioneering platform for genomic
    research with aCGH specific analysis and visualization.

    With ImaGene array Comparative Genomic Hybridization (aCGH)
    Module, you have all the features of ImaGene 8.0 delivering high quality
    data and advanced automation to quantify, normalize and analyze your
    experiments. And with this automation, you reduce the risks of operator
    error, making your data more reliable and your experiments
    reproducible.

    The aCGH Module is presented within ImaGene 8.0's user interface
    with advanced navigation that makes you productive in No time at all. In
    addition, the interactive integrated visualization tools enable you to
    quickly drill-down from a chromosomal region to a single spot on the
    array to ensure correct interpretation of results.

    ImaGene aCGH Module allows you to get a fine grain view of your
    sample's chromosomal data with advanced analytical
    features/capabilities that will make you confident in your data and its
    reproducibility.

    1) One-Button Quantification, Normalization and Analysis - the high
    degree of automation reduces operator error to ensure high quality and
    reliable data, and reproducible experiments.

    2) Change Point Detection Algorithm - ImaGene aCGH Module's
    statistical-based and customizable Gain / Loss Call Algorithm offers the
    best balance of speed and accuracy of results and puts you in control
    with user-defined algorithm parameters to filter out the noise from your
    experiments detecting chromosomal deletions and amplifications to
    your threshold requirements.

    3) Integrated & Interactive Chromosome Plots - advanced navigation
    provides the ability to visualize spot images, see corresponding data
    tables and analysis results down to individual spot deletions or
    amplifications, while viewing chromosome location. A special zoom
    function provides focus along a specific section of an individual
    chromosome.

    4) A variety of plot types for display or export as graphics files include --

    a) Summary Plot - Shows a complete summary of the data highlighting
    areas of gain / loss by coloring the ideograms as well as showing the
    raw values for all the spots.

    b) Overview Plot - Provides an overview of the whole genome indicating
    areas of gain (green) and loss (red). Double bars indicate high
    gain/loss.

    c) Whole Genome Plot - Shows the raw data for the whole genome
    arranging each chromosome end-to-end on the x-axis.

    d) Chromosome View - Allows the user to look at a single chromosome
    at a time and see the spots (circles), the call algorithm results
    (magenta line) and moving average (yellow line) all at the same time.

    e) Box-plot and the CGH report output file are also provided.

    5) Point and Click Analysis - with just a click of your mouse you can
    move from chromosome to chromosome or from spot to spot within a
    chromosome for rapid analysis and visual quality control (QC) of your
    experiment results.

    6) Interconnection with Web Resources - direct integration with
    University of California at Santa Cruz (UCSC) and Ensembl web-based
    resources to extend your research capability to the global research
    community.  

    7) Fully integrated into ImaGene 8.0 - easy to use, simply load the file
    and go to work - No separate software, and No unique data importing
    requirements.

    ImaGene 8.0 - Features You Can Rely On -- With ImaGene aCGH you
    can rely on all the proven capabilities of the fully integrated ImaGene
    8.0, including these core features.

    1) Automated spot finding and grid placement; 2) Spot & array-level
    automated quality control;

    3) Patented automated segmentation; 4) One-button batch processing;

    5) High quantification accuracy; 6) Intuitive interface design and
    navigation;

    7) Integrated and interactive analysis results; 8) Diverse system
    compatibility.

    Manufacturer   Home office; see web site for international locations.

    BioDiscovery, Inc.
    2121 Rosecrans Ave., Suite 3315
    El Segundo, CA 90245
    Tel: (310) 414-8100
    Fax: (310) 414-8111
    support@biodiscovery.com

    Manufacturer's Web Site  www.biodiscovery.com/index/imagene-cgh

    Price   Contact manufacturer

    G6G Product Number  20129

    G6G Manufacturer Number 100431
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