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    GenomeQuest

    Category  Cross-Omics>Sequence Analysis/Tools

    Abstract  GenomeQuest is a web-based, sequence information
    platform for managing and mining sequence data and is accessed
    through an in-house enterprise installation or secure, hosted
    application service provider (ASP) service. With GenomeQuest,
    bioinformaticians, scientists and Intellectual Property (IP) professionals
    alike can quickly explore biological sequence information while
    simultaneously investigating the intellectual property landscape.

    GenomeQuest allows you to search numerous public, commercial and
    private databases at once, execute any number of search strategies,
    and then quickly apply filtering parameters to deliver the answers you
    need to questions of research validity, freedom-to-operate, patent
    infringement, business opportunity, and more, all through an easy-to-
    use web interface.

    Product features/capabilities include:

    Sequence Patent Databases -- GenomeQuest houses one of the
    largest annotated sequence patent databases - GQ-PAT. The database
    is updated daily and contains 20x more sequence patents than
    GenBank and more annotations than RefSeq. The GQ-PAT database
    includes patent sequences from multiple patent databases - global
    patent offices, publicly available bio-sequence databases and web
    resources including: United States Patent and Trademark Office
    (USPTO); European Patent Offices (EPO); patents posted online by
    World Intellectual Property Organization (WIPO) / Patent Cooperation
    Treaty (PCT) or with US equivalents. The International Patent
    Documentation Center (INPADOC) family of information allows the
    manufacturer to extend its coverage to secondary issuing offices.

    GQ-PAT data is both automatically filtered and manually curated to
    detect and eliminate errors originating from source databases to
    ensure consistency and accuracy. Data from all sources is processed
    in GenomeQuest’s proprietary automated pipeline into GQ-PAT to make
    the sequences as well as all annotations searchable and browsable.

    Biological Sequences -- With GenomeQuest the latest sequence data
    is all in one place. Information from public nucleotide and protein
    sequence databases including GenBank, Affymetrix, ENSEMBL, NCBI
    ProbeDB, Ig Blast, and RefSeq are all accessible. GenomeQuest also
    offers DrugBank Pro, a drug target database, which combines
    pharmacological information with sequence, and structure, as well as
    Investigational New Drug (IND) information. License holders can
    access GeneSeq data through GenomeQuest, as well.

    Flexible Sequence Search -- Not all search algorithms are created
    equal so GenomeQuest gives you four (4) different search algorithms to
    choose from including Basic Local Alignment Search Tool (BLAST),
    Percent Identity (GenePAST), Fragment Search, and Motif/Pattern
    Search. Each strategy includes a set of parameters that can be
    adjusted for your sequence.

    GenePAST - Also referred to as Percent Identity, GenePAST search is
    used to strictly look for percent identity of one sequence against
    another. This is ideal for short sequence searchers because, unlike
    BLAST, GenePAST is non-heuristic and allows the user to specify
    percentage identity on the sequence itself. GenomeQuest also offers
    Fragment search to find alignments between fragments that are
    common between query and subject sequences.

    As well as Pattern Matching, that makes necessary allowances for
    ambiguity in your query sequence. Pattern Matching works with Prosite
    (database) patterns, regular expressions and the International Union of
    Pure and Applied Chemistry (IUPAC) ambiguity codes for nucleotides
    and amino acids.

    Keyword Search -- GenomeQuest keyword search enables you to find
    sequences using a keyword located in the annotation. Search GQ-PAT
    or choose a protein or nucleotide database directly from the database
    tree to run the search against. GenomeQuest provides a list of default
    fields searched within each database during the keyword search.

    Results can be narrowed down by filtering on default fields as well as
    exported to a Word or Excel report. View annotation details or the
    sequence itself, by selecting appropriate tabs.

    Advanced Results Management -- Once GenomeQuest has run your
    search, you can easily navigate through a series of tabs, to apply one of
    many content dependent functions against the results.

    FilterSmart Technology -- Some searches return hundreds or
    thousands of results. GenomeQuest’s FilterSmart technology enables
    flexible and fast analysis of search results. Simultaneously filter on any
    number of alignment and/or annotation properties through simple pull-
    down menus, reducing results to highly relevant sequences in minutes.
    Based on the search strategy chosen, FilterSmart parameters are
    populated for only those fields available in the results. For instance
    filters applied to GenePAST results might include sequence identifier,
    alignment statistics, query length, patent filing date and legal status
    (granted or application), which enables you to determine and filter on
    whether a patent is granted.

    Application Launching -- Further manage results by launching
    sequence analysis applications e.g. ClustalW, Extensible Markup
    Language (XML) for BizInt Smart Charts, or others which may or may
    Not be native to GenomeQuest. With an enterprise installation of
    GenomeQuest users can add on their own sequence analysis
    applications.

    Alerting -- Stay abreast of updates to a chosen search. When you set an
    alert on a sequence search in GenomeQuest, the exact same search is
    run [same query, strategy, parameters, and database(s)] every time any
    one of the databases is updated. Then GenomeQuest automatically
    notifies you via e-mail if new results are found.

    Reporting -- Whether producing reports for your customers or sharing
    results with a colleague, GenomeQuest makes it easy. Instantly run
    reports using pre-existing templates or create custom reports based on
    data selections. GenomeQuest reports provide a full audit trail detailing
    your search filters, parameters, database strategies, etc. Reports can
    be produced in Excel or Word formats.

    Exporting -- GenomeQuest enables you to export sequences into a text
    file for analysis in another application. You can either use filtering or
    select the sequences by hand.  Formats for export include FASTA,
    GenBank or EMBL.

    Saving and Sharing Results -- GenomeQuest automatically saves all
    search results and houses them in My GenomeQuest - a central
    repository of searches you can organize into project folders and then
    allow others users to access, for collaboration and information sharing.

    The Right Fit -- Get the right combination of access, economy, and
    security to make GenomeQuest fit your usage and business needs with
    two (2) access choices.

    GQLive! -- If you’d like to get started searching today, sign up for GQLive!
    GQLive! a secure, hosted Internet service providing GenomeQuest
    biological sequence search, content, and analysis.

    Enterprise Installation -- GenomeQuest offers those looking for internal
    hosting and data access; onsite installation of GenomeQuest. This
    includes the GenomeCast Update Service, a through-the-firewall
    updating service that delivers content to keep your data current. Add
    functionality with the GQ ContentManager module which enables you to
    integrate your own proprietary data into GenomeQuest, so you can
    search your in house data along side the data produced by
    GenomeQuest.

    System Requirements  

    Contact manufacturer

    Manufacturer   Home office; see web site for international locations.

    GenomeQuest, Inc.
    1700 West Park Drive, Suite 260
    Westborough, MA 01581
    Phone: 508-616-0100
    Fax: 508-616-0110
    contact-us@genomequest.com

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