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Category Genomics>Genetic Data Analysis/Tools Abstract Nexus Copy Number is an easy to use yet advanced tool for analyzing and visualizing array comparative genomic hybridization (CGH) data. Nexus provides cross platform copy number analysis on multiple experiments containing multiple samples providing comprehensive gain and loss frequency analysis, statistical confidence values, class comparison analysis, and genomic based clustering. Products features/capabilities include: Platform Independent -- Direct support for commercial arrays - Affymetrix, Agilent, Illumina, Nimblegen, Empire Genomics, ImaGene, GenePix, BlueFuse, and custom file format support. Nexus lets you integrate between different array types. Identify Regions of Common Aberrations -- Nexus Copy Number allows the creation of a Frequency plot indicating what percentage of the selected population has a particular Copy Number Aberration (CNA). Its “sort” tool allows the user to sort the samples based on the presence and size of the CNA at a selected location. Drill-Down to A Single Sample -- Nexus Copy Number lets you get all available probe level data and complete cytogenetic visualization of a single sample with a single mouse click. Quickly Find Genes and Regions -- With Nexus you can type in a gene symbol or genomic region and have Nexus immediately zoom into the desired region showing samples and any genomic aberrations at that location. Statistical Significance -- Nexus lets you identify regions of statistical significant CNA at a specified p-value with a single click. You can also export these regions or drill-down to genes and biological functions with a single mouse click. Visualize Copy Number Profiles Between Groups -- Simultaneously view copy number profiles for any groupings of samples (e.g., different tumor types) along with the overall dataset profile. Nexus lets you mouse over any area and see the percentage of samples within a call having a specific aberration. Identify Statistically Significant Regions Between Groups -- Create any pair-wise grouping of samples and perform statistical testing between groups for significant regions. For example, identification of regions with different CNA profiles between young and sick samples as compared to old and healthy cases. Visualize Regions of Significance Differences -- Create specific graphical plots for pair-wise comparisons highlighting areas of significant difference between the groups. Access All Annotations With a Single Click -- For each region of interest, you can create an annotation report listing, genes, gene function, gene ontology (GO) terms, probe information, and much more with only a single mouse click. Perform Enrichment Analysis -- Identify Biological processes, molecular functions, and cellular components that could be affected by changes in copy number. Cluster Samples Based on Genomic Changes -- Nexus lets you cluster samples based on CNA profiles for each sample. You can also use hierarchical or k-means clustering. Note: See G6G Product Number 20128 and G6G Product Number 20129 for additional product info from this manufacturer. System Requirements Platforms Supported: Windows Win2k/WinXP, OS X Minimum: 1.0 GHz Pentium or G4, 512 MB RAM Recommended: 2.0 GHz or faster Core 2 Duo, 1024 or more MB RAM Manufacturer Home office; see web site for international locations.
2121 Rosecrans Ave., Suite 3315 El Segundo, CA 90245 Tel: (310) 414-8100 Fax: (310) 414-8111 support@biodiscovery.com Manufacturer's Web Site www.biodiscovery.com/index/nexus Price Contact manufacturer G6G Product Number 20132 G6G Manufacturer Number 100431 |
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