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    ChipInspector

    Category  Genomics>Gene Expression Analysis/Profiling/Tools

    Abstract  ChipInspector extracts significant information right from the
    expression level of single probes from microarrays. Sophisticated
    analysis techniques and state-of-the-art genomic knowledge
    dramatically increase the number of significant features while
    simultaneously reducing false positive rates by an order of magnitude.
    Start with your existing Affymetrix data (CEL files) to see what is really
    behind the data.

    ChipInspector uses one of the world's largest databases of alternative
    transcripts and promoters to achieve superior signal-noise ratios in
    microarray analysis. It is unique in removing statistical and gene calling
    errors right at single probe level. This technology provides the basis for
    unmatched accuracy in the significance analysis of microarray (SAM)
    data.

    Products features/capabilities include:

    1) ChipInspector uses single probe expression levels as input.

    2) ChipInspector reduces false positive rates by about an order of
    magnitude.

    3) ChipInspector eliminates normalization/interpolation problems.

    4) ChipInspector increases the number of significant features.

    5) ChipInspector supports Affymetrix CEL (cell intensity) files (other
    platforms are possible).

    6) ChipInspector assigns probes correctly to transcripts and genes.

    7) ChipInspector accounts for alternative transcripts.

    8) ChipInspector offers a direct transcript view with probe mapping.

    9) ChipInspector applies state-of-the-art genomic knowledge.

    10) ChipInspector extracts new information by mining previous
    microarray experiments.

    11) ChipInspector results are directly usable as input to the
    BiblioSphere Pathway Edition (see G6G Product Number 20019)
    product.

    Note: An Example of a regular SAM analysis vs. ChipInspector --

    An example experiment with very good results, based on Affymetrix
    probe set analysis. A SAM analysis with a false positive rate of 0.2 %
    yields an ‘experiment specific network’ with 14 genes linked to four (4)
    pathways. But some key genes known to be involved remain
    unconnected to observed pathways.

    Re-evaluation of the identical experiment with ChipInspector on a single
    probe level allows a SAM analysis with a false positive rate of 0.002%.
    The identical network analysis yields an ‘experiment specific network’
    with 35 significantly regulated genes joined and linked to 31 pathways.
    All known key genes are included in the network.

    System Requirements  

    One of the following operating systems:
    Windows 9x, 2000, XP
    (Please contact support@genomatix.de for installation on XP 64-bit!)
    Linux/Unix, MacOS X (at least 10.4)
    Java 1.5.0_06 or higher.
    Internet connection
    512 MB main memory

    Manufacturer   Home office; see web site for international locations.

    Genomatix Software GmbH
    Bayerstr. 85a
    80335 München
    Germany
    Phone: +49-89-599-766-0
    Fax: +49-89-599-766-55
    email: info@genomatix.de
    sales: sales@genomatix.de

    Manufacturer's Web Site  www.genomatix.de/products/ChipInspector/

    Price   Contact manufacturer

    G6G Product Number  20133

    G6G Manufacturer Number 101114
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