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Category Proteomics>Mass Spectrometry Analysis/Tools Abstract ProteoIQ by BioInquire, is one of the most advanced software products for comparative and quantitative proteomics. Built for a demanding research environment, ProteoIQ supports the entire proteomic data analysis pipeline, from statistical validation to quantification. ProteoIQ features/capabilities include: Custom Grouping -- Describe Your Proteome - 1) Organize your Search Results; 2) Group by Multidimensional Chromatography Coupled with Tandem Mass Spectrometry (MudPIT) or Two-Dimensional Gel Electrophoresis (2D PAGE) or; 3) Choose Custom File Grouping; Unlimited biological groups or replicates. Describe Your Samples - 1) Assign unique Descriptions for each biological Group; 2) Assign Replicates; 3) All Data keeps their Assigned Names (spectral counts, peptide scores, sequence coverage, et al); 4) Collaborators and Customers can Interpret with Ease. Grouping Files - 1) Match Database search results with Biological Samples or Replicates; 2) Drag-and-Drop Efficiency; 3) Quick and Easy Sorting; 4) Add Multiple search Results for the same Tandem Mass Spectrometry (MS/MS) file; 5) Monitor Changes in your Separation Scheme. Statistical Validation -- False Discovery Rates - 1) Estimate global error rates with false discovery rate calculations at the protein and peptide level; 2) Use either separate or merged target and decoy databases; 3) Limit the frequency of random assignments; 4) Generate plots based on Mascot (see G6G Product Number 20087) or SEQUEST scores, discriminate scores or probabilities. Probability - 1) Model distributions of correct versus incorrect assignments; 2) Assess reliability using a visual representation; 3) Save results as images or as text. Assess Sensitivity and Error - 1) Create an effective balance between sensitivity and allowable error; 2) Maximize the number of protein identifications by choosing how to filter data; 3) Maintain an acceptable error rate. Comprehensive Data Reporting - 1) Display all scores and metrics associated with every peptide and protein assignment; 2) Track how protein sets are filtered; 3) Customize results views to fit your needs. Proteome Visualization -- View Proteins and Peptides - 1) No need for endless spreadsheets; 2) User-friendly interface displays every identified protein or peptide; 3) Sort, search and compare differences between samples; 4) Sort results based on over 33 key metrics. Customizable Results View - 1) Tailor how you view results; 2) Display only data important to your research; 3) Create custom views for each client or collaborator. Protein Sequence View - 1) Focus on key proteins and peptides; 2) Access detailed information about every protein identification; 3) Reveal protein sequence coverage, peptide modifications and relative expression between biological groups; 4) Hyperlink to important biological databases. Comparative Proteomics -- Find Differences and Similarities 1) Select protein sets and choose from three comparisons functions; 2) Compare by difference or intersection; 3) Use the “Union” function to merge protein sets. Label Free Quantification -- Create Scatter Plots - 1) Compare spectral count abundances to one or more biological samples; 2) Monitor reproducibility using dynamic charts; 3) Find truly significant deviations in protein expressions. Create Heat Maps - 1) Create customizable heat maps; 2) Select which samples to display and the type of metric; 3) Choose formatting for the table; 4) Save heat maps as images; 5) Use results in other software applications. Refine your search -- Create Subset Databases - 1) Create a FASTA database from your identified proteins; 2) Repeat searches with unlimited Post Translational Modifications (PTMs) or enzyme cleavage rules; 3) Submit FASTA database to Basic Local Alignment Search Tool (BLAST) or Signal peptide prediction and localization (SignalP). Group Many Search Results From a Single MS/MS File - 1) Combine results from multiple database searches; 2) Expand your proteome coverage by using many modifications or enzyme cleavage rules; 3) For example, a strict tryptic cleavage search and a semi tryptic cleavage search can be combined. Filter Results by Modification or Enzyme Specificity - 1) Easily filter results using the “Filter Pane”; 2) Choose from specific modifications or cleavage rules used during the search. Collaborate and Share -- Free ProteoIQ Viewer - 1) Share results easily, No cumbersome spreadsheets needed; 2) Validate protein identifications before sharing with customers; 3) Give clients freedom to compare and manipulate results. Export Results in Multiple Formats - 1) Export Protein and Peptide Identifications as text files; 2) Use results for further analysis in other programs; 3) Create FASTA file of identified protein sequences; 4) Use to further search or submit to biological databases. Publish Proteomics Data to the Web - 1) Create dynamic web pages of your proteomics results; 2) Publish protein and peptide identifications to the web; 3) Share data with collaborators remotely. Database Wizard -- Database Management Made Simple - 1) Automatic error checking provides accurate results; 2) Select your database; 3) Name, assign, and describe on one page; 4) Follow the intuitive, step-by-step Wizard. Link Protein Identifications to External Biological Databases - 1) Hyperlink to public or local databases; 2) Link protein identifications to GenBank ( is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations), SwissProt (a manually curated biological database of protein sequences), or Gene Data Base (GeneDB); 3) Use the Protein Viewer for easy navigation. Subtractive Proteomics Enabled - 1) Non-target database search strategy; 2) Compare search results between two (2) different databases; 3) Filter out contaminating spectra; 4) Identify novel protein identifications in RNA or DNA databases. System Requirements Contact manufacturer Manufacturer Home office; see web site for international locations.
220 Riverbend Rd. Suite 103 Athens, GA 30602 Phone: (706) 583-4000 Toll Free: (888) 291-2BIO Fax: (706) 583-4037 Manufacturer's Web Site www.bioinquire.com/ Price Contact manufacturer G6G Product Number 20201 G6G Manufacturer Number 100429 |
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