Bio Resource for Array Genes

Category Cross-Omics>Knowledge Bases/Databases/Tools

Abstract Bio Resource for Array Genes is a free online resource for easy access to collective and integrated information from various public biological resources for human, mouse, rat, fly and c.elegans genes.

This Bio Resource is a platform designed as an online resource to assist researchers in analyzing results of microarray experiments and developing a biological interpretation of the results.

This site is mainly to interpret the unique gene expression patterns found as biological changes that can lead to new diagnostic procedures and drug targets.

This interactive site allows users to selectively view a variety of information about gene functions that is stored in an underlying database.

Although there are other online resources that provide a comprehensive annotation and summary of genes, this resource differs from these by further enabling researchers to mine 'biological relationships' amongst the genes captured in the database using new query tools.

Thus providing a unique way of interpreting the microarray data results based on the knowledge provided for the cellular roles of genes and proteins.

A total of six (6) different query tools (see below) are provided and each offer different search features, analysis options and different forms of display and visualization of data.

The data is collected in a relational database from public resources: UniGene, Locus link, OMIM, NCBI dbEST, protein domains from NCBI CDD, Gene Ontology (GO), Pathways [Kegg, GenMAPP (see G6G Abstract Number 20219) and Biocarta] and BIND (Protein interactions). Data is dynamically collected and compiled twice a week from public databases.

Search options offer the capability to organize and cluster genes based on their Interactions in biological pathways, their association with Gene Ontology terms, Tissue/organ specific expression or any other user- chosen functional grouping of genes.

A color coding scheme is used to highlight differential gene expression patterns against a background of gene functional information. Concept hierarchies (Anatomy and Diseases) of MESH (Medical Subject Heading) terms are used to organize and display the data related to Tissue specific expression and Diseases.

Data Collected --

All the data is collected from external resources and hence the annotation quality and accuracy is as provided by the parent annotation resources.

This Resource collects data from various 'open public resources' and integrates them together in a relational schema which can be further accessed through a common platform.

For some of these external data resources there are terms governing use of their site and data. Wherever applicable you should review their terms of agreement before using the data.

Query Tools --

1) Pathway Miner - Classify and Extract a network of Associated Genes/Proteins based on Kegg, Biocarta and GenMapp Pathways.

2) Genes - Collective information from various public biological resources for genes.

3) Protein Interactions & Complexes - Search interactions and complexes and view the interaction networks.

4) Tissues - View tissue specific expression for genes - (human and mouse).

5) Disease Finder - Search and analyze genes associated with Disease - (human).

6) GO terms - Classify Genes based on Gene Ontology (GO) Terms - (human and mouse).

System Requirements

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Manufacturer

Manufacturer Web Site Bio Resource for Array Genes

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G6G Abstract Number 20239

G6G Manufacturer Number 102851