Category Cross-Omics>Data/Text Mining Systems/Tools

Abstract NextBio is a life science search engine that enables researchers and clinicians to access and understand the world's life sciences information. With NextBio, in just one click you can search through tens of thousands of study results with 'billions' of data points spanning across different experimental platforms, organisms and data types. NextBio also searches across millions of publications to help you find new articles pertaining to your query.

NextBio's search engine makes massive amounts of disparate biological, clinical and chemical data from public and proprietary sources searchable, regardless of data type and origin, and empowers scientists to quickly understand their own experimental results within the context of other research.

NextBio is designed to be used by anyone interested in basic and clinical research, drug discovery or biology. Through NextBio you can understand the function of your genes of interest and their roles in disease, identify novel biomarkers, discover associations between diseases, treatments and tissues, or place your own data within the context of the world's experimental results.

The literature search enables you to quickly place any interesting findings within the context of published articles. You can also collaborate with other researchers using NextBio.

NextBio content (see below) includes pre-processed data from the public resources such as NCBI GEO [Gene Expression Omnibus - (see G6G Abstract Number 20013)], ArrayExpress (see G6G Abstract Number 20012), SMD (Stanford Microarray Database), and many others. In addition, individual organizations and users contribute data to NextBio for the benefit of the entire scientific community. Users and organizations can also keep their data private and share it with a select group of individuals.


1) Data points -- NextBio searches 1.2 billion data points from tens of thousands of study results and multiple experimental platforms.

2) Literature -- Search over 17 million articles as you would in PubMed only to get enhanced results. Firstly, NextBio's heuristics include 'intelligent features' such as inclusion of synonyms for a more comprehensive set of results. Secondly, in one click, you are able to search a larger universe: literature + data, genes, biogroups, compounds, diseases and tissues.

3) Compounds -- NextBio searches on 8 million compound clusters that are accessible through any of the multiple synonyms each are referenced by. For instance, some of the many terms you can use to find the chemical, morphine in NextBio: morphine, dreamer [street name], morfina [Italian], Roxanol [brand name], 64-31-3 [CAS no.] and 5288826 [PubChem ID].

4) Genes -- NextBio enables you to search genes using universal gene identifiers, such as GenBank accession numbers, as well as platform- specific identifiers such as those corresponding to Affymetrix, Illumina, Agilent and GE (General Electric). Furthermore, genes are connected to their cross-species homologues so your data search automatically spans all available models.

5) Tissues -- Thousands of tissues concepts built on an ontology incorporating the multitude level relationships between anatomical parts.

6) Diseases -- Over 65,000 comprehensive Disease concepts.

7) Biogroups -- Over 24,000 Biogroups including functional gene sets grouped by shared gene ontologies (GO) pathways, regulatory motifs, miRNA-target sequences and more.

8) Studies -- Search over 10,000 study results classified by therapeutic area.

9) Organisms -- Search for genes and studies from Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Drosophila melanogaster and Caenorhabditis elegans.

NextBio currently supports any type of gene-centric data (gene expression, proteomics, siRNA screens, etc.) for human, mouse, rat, fly, worm and yeast. NextBio is actively working on adding support for monkey, plants and many other organisms.

Searching all publicly available data and literature in NextBio is free. Moreover, with free registration, you can import and correlate an unlimited amount of your own private data if it is made public to the community, save study results as bookmarks and forward those to colleagues create your own user profile, and research projects and publications.

NextBio also provides a subscription-based premium version of its product accessible in a private and secure enterprise domain with special Application Programming Interfaces (APIs) for unlimited private data import, customized categorization of search results and reporting, an administration dashboard for user access control and settings, and technical support.

System Requirements



Manufacturer Web Site NextBio

Price Free and subscription-based premium version (see above).

G6G Abstract Number 20175

G6G Manufacturer Number 101977