Bruker BioSpin AMIX

Category Metabolomics/Metabonomics>Metabolic Profiling/Analysis Systems/Tools and Proteomics>Mass Spectrometry Analysis/Tools

Abstract Bruker BioSpin’s AMIX (Analysis of MIXtures) system provides a collection of advanced tools that enable you to get the most out of your data. AMIX provides many integrated routines for statistical and spectroscopic analyses.

Productivity for a wide variety of applications, such as metabolomics, small molecules research and mixture analysis are enhanced.

Unique is the combined analysis of NMR and MS data. In many applications like ‘structure verification’ they confirm each other while in other applications like metabolomics they are also complementary.

You benefit from a customizable user interface and highly optimized performance. Apart from general analysis tools, a set of specialized tool-kits are offered for different applications. They may be run individually or in combined mode.

AMIX provides:

1) Straightforward Evaluation of multi-modality data up to 4 dimensions [NMR, LC-NMR, Mass Spectrometry (MS), Liquid Chromatography-Mass Spectrometry (LC-MS), Fourier Transform-Mass Spectrometry (FT-MS), and ultraviolet (UV)];

2) A complete set of Spectra Analysis Tools including spectra algebra, pattern recognition, pattern exploration, high through-put tools, complete peak and multiple analysis, and data matching;

3) A family of data manipulation and data management tools to prepare spectra and build up your own spectra bases;

4) A SQL interface to optionally store and use spectra directly in an ORACLE data base;

5) Tools for relative or absolute quantification including peak integration by line shape analysis, peak modeling, maximum entropy methods, and pattern quantification;

6) A command mode that allows important functionality like bucket table calculation and spectra matching to be executed in other program environments, e.g. in TopSpin Au programs - (TopSpin™ is a software package for the acquisition, processing and analyzing of NMR data).

Major AMIX tool-kits include:

1) Analytical Profiling of complex mixtures.

2) Metabolomics.

3) Protein-ligand screening.

4) Spectra bases.

5) Structure verification of small molecules.

1) Analytical Profiling of complex Mixtures -- features/capabilities --

AMIX offers a profiling module for the identification and quantification of complex mixtures. Spectral and molecular information are provided in a spectra base and knowledge base (KB). It applies to 1D and 2D NMR as well as LC-MS spectra.

2) Metabolomics -- features/capabilities --

AMIX fully integrates spectroscopic and statistical analysis of Nuclear Magnetic Resonance (NMR), High-Performance Liquid Chromatography (HPLC) and Life Sciences-Mass Spectrometry (LS-MS) data to better find valid metabolomic results.

3) Protein-Ligand Screening -- features/capabilities --

AMIX fully supports the analysis of protein-ligand binding combining interactive and automated tools. Effects of binding can be studied in spectra of labeled proteins or unlabelled ligands. Application to a large series of spectra is possible.

Receptor based techniques -

Ligand based techniques -

Automated 1D matching techniques -

4) Spectra Bases and Data Bases -- features/capabilities --

AMIX contains all the necessary tools to build up your own spectra bases or use Bruker‘s commercial spectra base. Spectra are cleaned-up and assigned before being stored in a special compressed format.

Automation and history tracking allows fast batch processing. User defined keys, molecular information, and links to external data bases can be attached to spectra. Storage is possible on disk or in SQL data bases such as ORACLE.

Note: Efficient selection of data is available in all major AMIX tool-kits.

5) Structure Verification of Small Molecules -- features/capabilities --

AMIX offers a verification suite to utilize characteristics of the chemical synthesis if available and shift prediction otherwise. 1D and 2D HSQC spectra may be used.

Tools are fully or semi-automated. Efficient visual inspection via color coded result panels and text tables. Any technique can be combined with a fully automated LC-MS analysis.

Key features of the LC-MS analysis are:

System Requirements

AMIX is offered for Windows, Linux and UNIX platforms.


Manufacturer Web Site Bruker BioSpin AMIX

Price Contact manufacturer.

G6G Abstract Number 20657

G6G Manufacturer Number 104304